How Legalizing Organic Drugs Is the Only Way to Win America’s Chemical War with China
February 25, 2026
The pharmacological difference between natural THC and synthetic cannabinoids like K2 is the difference between a partial agonist and a full agonist. THC, the active compound in cannabis, partially activates the CB1 receptor in your brain. There is a biological ceiling on how activated that receptor can get from natural cannabis. This is why a fatal marijuana overdose is, for all practical purposes, impossible.